Dual-Antiplatelet Therapy for Diabetic Patients After Stent Implantation

Antiplatelet therapy and stent thrombosis after sirolimus-eluting stent implantation.

BACKGROUND The influences of antiplatelet therapy discontinuation on the risk of stent thrombosis and long-term clinical outcomes after drug-eluting stent implantation have not yet been addressed adequately. METHODS AND RESULTS In an observational study in Japan, 2-year outcomes were assessed in 10 778 patients undergoing sirolimus-eluting stent implantation. Data on status of antiplatelet th...

Double Antiplatelet Therapy After Drug-Eluting Stent Implantation

Ignacio Ferreira-González, MD, PHD,*† Josep R. Marsal, BSC,*†‡ Aida Ribera, PHD,*† Gaietà Permanyer-Miralda, MD, PHD,*† Bruno Garcı́a-Del Blanco, MD,* Gerard Martı́, MD,* Purificación Cascant, RN,*† Mónica Masotti-Centol, MD, PHD,§ Xavier Carrillo, MD, Josepa Mauri, PHD, Nuria Batalla, MD,¶ Eduard Larrousse, MD,# Eva Martı́n, MD,** Antonio Serra, MD,†† José Ramón Rumoroso, MD,‡‡ Rafael Ruiz-Salmer...

Six Versus 12 Months of Dual Antiplatelet Therapy After Implantation of Biodegradable Polymer Sirolimus-Eluting Stent

Individualization of dual antiplatelet therapy duration after drug-eluting stent implantation: paradigm and reality.

The use of drug-eluting stents (DES) results in a dramatic reduction in restenosis and represents one of the major advances in interventional cardiology. Yet, a reduction in death and myocardial infarction could not be shown with these devices; instead there were concerns about an excess of late thrombotic events compared with bare metal stents (BMS). The key underlying pathophysiological mecha...

Diverticular bleeding complicating dual antiplatelet therapy after drug-eluting stent implantation

Acute lower gastrointestinal bleeding is defined as a bleeding situation in which blood loss has been occurring for less than 3 days resulting in haemodynamic instability, anaemia, or the need for blood transfusion. Diverticula and angiectasias are the most frequent sources of bleeding. Malignancy, inflammatory bowel disease, non-steroidal anti-inflammatory drugs, infectious colitis, ischaemia,...